(NewsNation) — As millions of Americans begin to drive and fly home after Thanksgiving, a heavy snowstorm was moving through the Midwest and the Northern Plains on Friday.
The storm system is set to cross the entire country, with 46 million people under new winter storm alerts, from Massachusetts to Montana.
Saturday is expected to see the most significant effects across the Great Lakes region of the Midwest.
Travel officials said disruptions are possible throughout the holiday weekend due to the wintry weather. People flying through Chicago, Detroit, Minneapolis or Kansas City, Missouri, should be especially alert.
Up to 15 inches are possible in parts of Iowa and western Illinois, and areas downstream of the Great Lakes are expected to get six to 12 inches.
Most of the snow will clear by Sunday and move into Canada, but the Great Lakes region will likely still experience travel impacts. Sunday is expected to be the busiest travel day of the holiday weekend.